TNFAIP3 (NM_006290) Human Tagged ORF Clone Lentiviral Particle
Referentie RC221337L2V
Formaat : 200ul
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| Product Data | |
| Tag | mGFP |
|---|---|
| Target Symbol | TNFAIP3 |
| Synonyms | A20; AISBL; OTUD7C; TNFA1P2 |
| Vector | pLenti-C-mGFP |
| Mammalian Cell Selection | None |
| Sequence Data | ORF Nucleotide Sequence The ORF insert of this clone is exactly the same as(RC221337). |
| ACCN | NM_006290 |
| ORF Size | 2370 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_006290.3 |
| RefSeq Size | 4705 bp |
| RefSeq ORF | 2373 bp |
| Locus ID | 7128 |
| UniProt ID | P21580 |
| Cytogenetics | 6q23.3 |
| Domains | zf-A20 |
| Protein Families | Druggable Genome |
| Protein Pathways | NOD-like receptor signaling pathway |
| MW | 90.1 kDa |
| Summary | This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012] |
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