Umifenovir [131707-25-0]
Referentie HY-14904-10mg
Formaat : 10mg
Merk : MedChemExpress
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.
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Umifenovir Chemical Structure
CAS No. : 131707-25-0
This product is a controlled substance and not for sale in your territory.
Based on 8 publication(s) in Google Scholar
Other Forms of Umifenovir:
- Umifenovir hydrochloride In-stock
Description |
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3]. |
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In Vitro |
Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Umifenovir (25 and 45 mg/ml; p.o.) shows a survival benefit to mice suffering from influenza infection[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
477.41 |
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Formule |
C22H25BrN2O3S |
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CAS No. |
131707-25-0 |
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Appearance |
Solid |
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Color |
Off-white to light yellow |
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SMILES |
O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvant et solubilité |
In Vitro:
DMSO : 50 mg/mL (104.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.0946 mL | 10.4732 mL | 20.9464 mL | 52.3659 mL |
5 mM | 0.4189 mL | 2.0946 mL | 4.1893 mL | 10.4732 mL | |
10 mM | 0.2095 mL | 1.0473 mL | 2.0946 mL | 5.2366 mL | |
15 mM | 0.1396 mL | 0.6982 mL | 1.3964 mL | 3.4911 mL | |
20 mM | 0.1047 mL | 0.5237 mL | 1.0473 mL | 2.6183 mL | |
25 mM | 0.0838 mL | 0.4189 mL | 0.8379 mL | 2.0946 mL | |
30 mM | 0.0698 mL | 0.3491 mL | 0.6982 mL | 1.7455 mL | |
40 mM | 0.0524 mL | 0.2618 mL | 0.5237 mL | 1.3091 mL | |
50 mM | 0.0419 mL | 0.2095 mL | 0.4189 mL | 1.0473 mL | |
60 mM | 0.0349 mL | 0.1746 mL | 0.3491 mL | 0.8728 mL | |
80 mM | 0.0262 mL | 0.1309 mL | 0.2618 mL | 0.6546 mL | |
100 mM | 0.0209 mL | 0.1047 mL | 0.2095 mL | 0.5237 mL |
Umifenovir Related Classifications
- Anti-infection
- SARS-CoV Influenza Virus