Vinorelbine (ditartrate) [125317-39-7]
Referentie HY-12053A-1ml
Formaat : 10mM/1mL
Merk : MedChemExpress
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
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Vinorelbine ditartrate Chemical Structure
CAS No. : 125317-39-7
This product is a controlled substance and not for sale in your territory.
Based on 10 publication(s) in Google Scholar
Other Forms of Vinorelbine ditartrate:
- Vinorelbine-d3 ditartrate In-stock
- Vinorelbine Obtenir un devis
Description |
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. |
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In Vitro |
Vinorelbine (0.5-5 nM) ditartrate inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At a concentration of 8 nM, no cells are in anaphase[1]. Vinorelbine ditartrate time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine ditartrate stimulates reporter genes in a concentration-dependent manner[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
1079.11 |
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Formule |
C53H66N4O20 |
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CAS No. |
125317-39-7 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
CC[C@@]1(C=CCN2CC3)[C@@]2(11)[C@@]3(C(C=C([C@@](C4=C5C(C=CC=C6)=C6N4)(CC(C=C(CC)C7)(11)CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9(11)[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
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Structure Classification |
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Initial Source |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvant et solubilité |
In Vitro:
DMSO : 125 mg/mL (115.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 100 mg/mL (92.67 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation |
Purity: 99.88% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 0.9267 mL | 4.6334 mL | 9.2669 mL | 23.1672 mL |
5 mM | 0.1853 mL | 0.9267 mL | 1.8534 mL | 4.6334 mL | |
10 mM | 0.0927 mL | 0.4633 mL | 0.9267 mL | 2.3167 mL | |
15 mM | 0.0618 mL | 0.3089 mL | 0.6178 mL | 1.5445 mL | |
20 mM | 0.0463 mL | 0.2317 mL | 0.4633 mL | 1.1584 mL | |
25 mM | 0.0371 mL | 0.1853 mL | 0.3707 mL | 0.9267 mL | |
30 mM | 0.0309 mL | 0.1544 mL | 0.3089 mL | 0.7722 mL | |
40 mM | 0.0232 mL | 0.1158 mL | 0.2317 mL | 0.5792 mL | |
50 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4633 mL | |
60 mM | 0.0154 mL | 0.0772 mL | 0.1544 mL | 0.3861 mL | |
80 mM | 0.0116 mL | 0.0579 mL | 0.1158 mL | 0.2896 mL | |
DMSO | 100 mM | 0.0093 mL | 0.0463 mL | 0.0927 mL | 0.2317 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Vinorelbine ditartrate Related Classifications
- Cell Cycle/DNA Damage Cytoskeleton Autophagy
- Microtubule/Tubulin Autophagy