Buccal cells provide a convenient source for DNA extraction, characterized by a straightforward and efficient process. Buccal saliva DNA extraction offers numerous advantages over other DNA collection methods, such as blood draws or tissue biopsies, in terms of being non-invasive, simple, and cost-effective for the donor.

For researchers, the method is less expensive and time-consuming, as it does not require specialized equipment or highly trained personnel. Furthermore, buccal saliva DNA extraction is particularly suited for studies requiring large sample sizes, such as genetic or epidemiological studies, with the ease of collection allowing for repeat samples from the same individual, thus facilitating longitudinal studies.