Anti-PDE5A antibody

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55 µg/µl
Dilution Range:	WB: 1:500-1:1, 000 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE5A
Gene ID:	8654
Uniprot ID:	PDE5A_HUMAN
Immunogen:	Recombinant protein common to all PDE5A variants corresponding to human PDE5A protein.

Tissue Specificity	Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Post Translational Modifications	Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Protein Name	Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase Cgmp-Binding Cgmp-Specific Phosphodiesterase Cgb-Pde
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-445355 Reactome: R-HSA-9013422
Alternative Antibody Names	Anti-Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase antibody Anti-Cgmp-Binding Cgmp-Specific Phosphodiesterase antibody Anti-Cgb-Pde antibody Anti-PDE5A antibody Anti-PDE5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance