Anti-TERF2 antibody (200-250) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.50 µg/µl
Dilution Range:	WB: 1:500-1:750 DB: 1:20, 000 ELISA: 1:20, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TERF2
Gene ID:	7014
Uniprot ID:	TERF2_HUMAN
Immunogen Region:	200-250
Immunogen:	Synthetic peptide taken within amino acid region 200-250 on human Telomeric repeat-binding factor 2 protein.

Tissue Specificity	Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
Post Translational Modifications	Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites. Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.
Function	Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
Protein Name	Telomeric Repeat-Binding Factor 2 Ttaggg Repeat-Binding Factor 2 Telomeric Dna-Binding Protein
Database Links	Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110330 Reactome: R-HSA-110331 Reactome: R-HSA-1221632 Reactome: R-HSA-171306 Reactome: R-HSA-171319 Reactome: R-HSA-174411 Reactome: R-HSA-174414 Reactome: R-HSA-174417 Reactome: R-HSA-174430 Reactome: R-HSA-174437 Reactome: R-HSA-2559586 Reactome: R-HSA-9670095
Cellular Localisation	Nucleus Chromosome Telomere Colocalizes With Telomeric Dna In Interphase Cells And Is Located At Chromosome Ends During Metaphase
Alternative Antibody Names	Anti-Telomeric Repeat-Binding Factor 2 antibody Anti-Ttaggg Repeat-Binding Factor 2 antibody Anti-Telomeric Dna-Binding Protein antibody Anti-TERF2 antibody Anti-TRBF2 antibody Anti-TRF2 antibody

Information sourced from Uniprot.org

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