Bacillus anthracis (Anthrax) Toxin Receptor, Control Peptide (ATR1, TEM8, Tumor Endothelial Marker 8)

Tumor Endothelial Marker 8 (TEM8), also called ATR1, is a glycoprotein of the anthrax toxin receptor family that is expressed by endothelial cells. Type I transmembrane isoforms of 564 aa (80-85 kD) and 368 aa (60 kD) and potentially secreted isoforms of 330 aa and 297 aa (45 kD) are differentially expressed. All diverge at the C-terminal end but share the N-terminal vWFA domain that binds the anthrax toxin PA subunit as well as collagens I and IV. Human TEM8 shares 99% aa identity with mouse and rat and 92% identity with dog and chick TEM8 within the extracellular domain.||Location: |13aa near the center of human ATR (1).||Applications: |The peptide is used for blocking the activity of ATR (IN) (TEM8) antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C. ||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.