Bcl-2 monoclonal Antibody, HRP Conjugated
Referentie bsm-33413M-HRP
Formaat : 100ul
Merk : Bioss
Bcl-2 monoclonal Antibody, HRP Conjugated
Applications
Reactivity
Overview | |
Catalog # | bsm-33413M-HRP |
Product Name | Bcl-2 monoclonal Antibody, HRP Conjugated |
Applications | WB |
Reactivity | Human, Mouse, Rat, Bovine, Dog, Pig, Sheep, Rabbit, Horse, Guinea Pig |
Specifications | |
Conjugation | HRP |
Host | Mouse |
Source | KLH conjugated synthetic peptide derived from human Bcl-2 |
Immunogen Range | 51-150/239 |
Clonality | Monoclonal |
Clone # | 4H1 |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein G. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 596 |
Swiss Prot | P10415 |
Subcellular location | Cytoplasm, Nucleus, Cell membrane |
Synonyms | Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN. |
Background | The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8). |
Application Dilution | |
WB | 1:300-5000 |