BRG1 (SMARCA4) Rabbit Polyclonal Antibody
Referentie TA322909
Formaat : 100ul
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| Product Data | |
| Application | IHC, WB |
|---|---|
| Application | WB: 200-1000 WB positive control: K562, 293T cells and hepG2 IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm, Nucleus |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 1460-1474 amino acids of Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member? |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Predicted Protein Size | 185 kDa |
| Gene Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI; which is required for transcriptional activation of genes normally repressed by chromatin. In addition; this protein can bind BRCA1; as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2 |
| Reference Data | |
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