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> Cholic acid-13C [52886-36-9]

Cholic acid-13C [52886-36-9]

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Referentie HY-N0324S2-10mg

Formaat : 10mg

Merk : MedChemExpress

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Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

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Cholic acid-<sup>13</sup>C Chemical Structure

Cholic acid-13C Chemical Structure

CAS No. : 52886-36-9

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Other Forms of Cholic acid-13C:

  • Cholic acid In-stock
Description

Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholic acid-13C Related Antibodies
Masse moléculaire

409.56

Formule

C2313CH40O5
CAS No.

52886-36-9
Unlabeled CAS

81-25-4
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@]2(04)[C@@]3(04)[C@@]([C@@](CC3)(04)[C@H](C)CC[13C](O)=O)([C@H](C[C@]2(04)[C@@]4([C@](C[C@@H](CC4)O)(04)C1)C)O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : ≥ 100 mg/mL (244.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4416 mL 12.2082 mL 24.4164 mL
5 mM 0.4883 mL 2.4416 mL 4.8833 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

    [2]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684.  [Content Brief]

    [3]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352.  [Content Brief]

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684.

    [3]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4416 mL 12.2082 mL 24.4164 mL 61.0411 mL
5 mM 0.4883 mL 2.4416 mL 4.8833 mL 12.2082 mL
10 mM 0.2442 mL 1.2208 mL 2.4416 mL 6.1041 mL
15 mM 0.1628 mL 0.8139 mL 1.6278 mL 4.0694 mL
20 mM 0.1221 mL 0.6104 mL 1.2208 mL 3.0521 mL
25 mM 0.0977 mL 0.4883 mL 0.9767 mL 2.4416 mL
30 mM 0.0814 mL 0.4069 mL 0.8139 mL 2.0347 mL
40 mM 0.0610 mL 0.3052 mL 0.6104 mL 1.5260 mL
50 mM 0.0488 mL 0.2442 mL 0.4883 mL 1.2208 mL
60 mM 0.0407 mL 0.2035 mL 0.4069 mL 1.0174 mL
80 mM 0.0305 mL 0.1526 mL 0.3052 mL 0.7630 mL
100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6104 mL
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Cholic acid-13C Related Classifications

  • Metabolic Disease
  • Metabolic Enzyme/Protease
  • Endogenous Metabolite
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholic acid-13C52886-36-9Endogenous MetaboliteInhibitorinhibitorinhibit