DAPT [208255-80-5]
Referentie HY-13027-5mg
Formaat : 5mg
Merk : MedChemExpress
DAPT (GSI-IX) est un inhibiteur de la γ-sécrétase puissant et oralement actif avec des IC50 de 115 nM et 200 nM pour un total < b>amyloïde-β (Aβ) et Aβ42, respectivement. DAPT inhibe l'activation de la signalisation Notch 1 et induit la différenciation cellulaire. DAPT induit également l'autophagie et l'apoptose. DAPT a une activité de neuroprotection et a le potentiel pour les maladies auto-immunes et lymphoprolifératives, les maladies dégénératives et le traitement du cancer.
DAPT (GSI-IX) ist ein potenter und oral wirksamer γ-secretase mit einem IC50s von 115 nM und 200 nM für Gesamtamyloid-β (Aβ) und Aβ42. DAPT hemmt die Aktivierung des Notch 1-Signals und induziert die Zelldifferenzierung. DAPT induziert auch autophagy und apoptosis. DAPT besitzt eine Neuroprotektionsaktivität und hat das Potenzial für die Behandlung von Autoimmun- und lymphoproliferativen Krankheiten, degenerativen Erkrankungen und Krebs.
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
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DAPT Chemical Structure
CAS No. : 208255-80-5
Based on 110 publication(s) in Google Scholar
Other Forms of DAPT:
- DAPT (GMP) In-stock
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DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Oct 19;246:114183. [Abstract]
- Detection of cell viability after treatment with different concentrations of DAPT (5 μM, 10 μM, 15 μM, 20 μM; for 24 h).
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DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Oct 19;246:114183. [Abstract]
- DAPT treatment enhances the protein expression of Bax and decreases the expression of Bcl2. And the expression of cleaved-caspase3 is upregulated after DAPT treatment (10 μM; for 24 h).
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DAPT purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2019 Mar;14(3):452-461. [Abstract]
- Western blot assay for Hes1 (left) and Hes5 (right) protein expression in the right prefrontal cortex of cerebral I/R mice following DAPT treatment.
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DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov;107:1370-1376. [Abstract]
- ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of Notch3, DTX1 and Hes1 are investigated by Western blotting.
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DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov;107:1370-1376. [Abstract]
- ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of LSD1 and H3K4me2 are investigated by Western blotting.
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DAPT purchased from MedChemExpress. Usage Cited in: Int J Cancer. 2018 Aug 1;143(3):645-656. [Abstract]
- Evaluation of expression change of Notch downstream under the androgen-deprived condition with or without the treatment of DAPT by western blot assay.
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DAPT purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Mar;233(3):2225-2237. [Abstract]
- DAPTprevents Nicd splitting from Notch1 and has been recognized as a Notch1 pathway inhibitor. Treatment with DAPT also inhibits the expression of Col IV and FN, resembling the effect of Notch1 siRNA.
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DAPT purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2018 Nov 8;12:3847-3854. [Abstract]
- Western anslysis of protein analysis of NOX2, NICD, Hes1, Hes5 in the treatment of TBI, TBI+vehicle, TBI+DAPT and TBI+DPI, respectively.
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DAPT purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2018 Oct 26;120(2):1903-1915. [Abstract]
- The distribution of aggrecan is increased in the DAPT group.
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DAPT purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Feb 15;13(2):e0193037. [Abstract]
- After DAPT treatment, the protein levels of Notch, Hes1 and Hes5 are downregulated in severe injury group. After DAPT treatment, the protein levels of Bcl-2 are upregulated while those of Bax, caspase-3 and caspase-9 are downregulated.
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DAPT purchased from MedChemExpress. Usage Cited in: World J Gastroenterol. 2017 Apr 7;23(13):2330-2336. [Abstract]
- Notch γ-secretase inhibitor attenuates notch and transforming growth factor-β signaling pathways in peripheral blood mononuclear cells of liver fibrosis rats. Western blot analysis of protein expression of Notch1, Hes1, Hes5, TGF-β and Smad3 and quantification in PBMCs (2 × 106) from rats treated with DAPT or DMSO for 24 h.
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DAPT purchased from MedChemExpress. Usage Cited in: Department Medicine. Yale University. 2016 Jan.
- Treatment with DAPT does not markedly alter expression of p27Kip1 in bulk or CD133- cells, but dramatically enhances its expression in CD133+ cells.