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> Ferrostatin-1 [347174-05-4]

Ferrostatin-1 [347174-05-4]

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Referentie 10-1380-5mg

Formaat : 5mg

Merk : Focus Biomolecules

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Ferrostatin-1 | Ferroptosis inhibitor

CAS:
347174-05-4
Catalog Number:
10-1380
Activity:
Ferroptosis inhibitor
Chemical Name:
Ethyl 3-amino-4-(cyclohexylamino)benzoate
Molecular Weight:
262.35
Molecular Formula:
C15H22N2O2
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

size : Quantity 
5 mg$45.00
25 mg$160.00
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Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1 Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1 Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2 Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.

References/Citations:

1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060
2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732
3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551
4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764

CAS:
347174-05-4
Catalog Number:
10-1380
Activity:
Ferroptosis inhibitor
Chemical Name:
Ethyl 3-amino-4-(cyclohexylamino)benzoate
Molecular Weight:
262.35
Molecular Formula:
C15H22N2O2
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1 Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1 Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2 Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.

References/Citations:

1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060
2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732
3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551
4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764