Clinisciences > GATA1 Antibody - N-terminal region : Biotin
GATA1 Antibody - N-terminal region : Biotin
Referentie P100834_P050-Biotin
Formaat : 100ul
Merk : Aviva Systems Biology
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Datasheets/Manuals | Printable datasheet for anti-GATA1 (P100834_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human GATA1 |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 92%; Sheep: 100% |
Peptide Sequence | Synthetic peptide located within the following region: SGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCME |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-GATA1 (P100834_P050) antibody is Catalog # AAP31190 (Previous Catalog # AAPP01933) |
Reference | de Gene 409 (1-2), 83-91 (2008) |
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Gene Symbol | GATA1 |
Gene Full Name | GATA binding protein 1 (globin transcription factor 1) |
Alias Symbols | GF1, GF-1, NFE1, XLTT, ERYF1, NF-E1, XLANP, XLTDA, GATA-1 |
NCBI Gene Id | 2623 |
Protein Name | Erythroid transcription factor |
Description of Target | GATA1 is a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Uniprot ID | P15976 |
Protein Accession # | NP_002040 |
Nucleotide Accession # | NM_002049 |
Protein Size (# AA) | 413 |
Molecular Weight | 43kDa |
Protein Interactions | KRTAP10-5; CCDC24; HEXIM2; FBF1; KRTAP9-2; RADIL; FRS3; PRKAB2; HSPB1; HOXA1; AKT1; SPIB; SPI1; PRKAA1; HSPA4; FLI1; CASP3; SRA1; SUMO1; CEBPE; MAPK6; UBC; SKI; NME1; RAI1; ZBTB22; TRIM25; TAF7; TAX1BP3; ZZZ3; TRIM29; IKZF1; Rb1; ZFPM1; ZNF521; ZBTB16; HD |
Protein interactions
Name | # of Products |
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AKT1 | 428 |
ARID1 | 3 |
CASP3 | 324 |
CEBPE | 68 |
CREBBP | 802 |
FLI1 | 26 |
HDAC5 | 906 |
HEY1 | 8 |
HSPA4 | 423 |
HSPB1 | 98 |
IKZF1 | 36 |
LMO2 | 55 |
MAPK1 | 575 |
MAPK3 | 444 |
MAPK6 | 386 |
MED1 | 185 |
MED14 | 82 |
MED17 | 52 |
NME1 | 64 |
RAI1 | 33 |
Rb1 | 474 |
SKI | 85 |
SP1 | 551 |
SPI1 | 86 |
STAT3 | 275 |
TAF7 | 68 |
TAL1 | 116 |
TAX1BP3 | 22 |
TRIM25 | 54 |
TRIM29 | 60 |
UBC | 7030 |
ZBTB16 | 145 |
ZBTB22 | 4 |
ZFPM1 | 18 |
ZFPM2 | 29 |
ZNF521 | 16 |
ZZZ3 | 32 |
Biological pathways
Name | # of Products |
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Basophil differentiation | 12 |
Cellular response to thyroid hormone stimulus | 16 |
Eosinophil fate commitment | 6 |
Erythrocyte development | 6 |
Megakaryocyte differentiation | 21 |
Negative regulation of transcription regulatory region DNA binding | 15 |
Platelet aggregation | 26 |
Platelet formation | 12 |
Positive regulation of anti-apoptosis | 118 |
Positive regulation of peptidyl-tyrosine phosphorylation | 308 |
Regulation of definitive erythrocyte differentiation | 6 |
Regulation of glycoprotein biosynthetic process | 3 |
Transcriptional activation by promoter-enhancer looping | 6 |
Biological process
Name | # of Products |
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Basophil differentiation | 2 |
Blood coagulation | 396 |
Cell-cell signaling | 235 |
Cellular response to cAMP | 28 |
Cellular response to follicle-stimulating hormone stimulus | 8 |
Cellular response to thyroid hormone stimulus | 8 |
Dendritic cell differentiation | 11 |
Embryonic hemopoiesis | 21 |
Eosinophil differentiation | 3 |
Eosinophil fate commitment | 2 |
Erythrocyte development | 12 |
Erythrocyte differentiation | 38 |
In utero embryonic development | 199 |
Male gonad development | 78 |
Megakaryocyte differentiation | 10 |
Negative regulation of apoptotic process | 356 |
Negative regulation of bone mineralization | 15 |
Negative regulation of cell proliferation | 375 |
Negative regulation of transcription from RNA polymerase II promoter | 574 |
Negative regulation of transcription regulatory region DNA binding | 13 |
Platelet aggregation | 14 |
Platelet formation | 9 |
Positive regulation of anti-apoptosis | 53 |
Positive regulation of osteoblast proliferation | 12 |
Positive regulation of peptidyl-tyrosine phosphorylation | 112 |
Positive regulation of transcription from RNA polymerase II promoter | 968 |
Regulation of definitive erythrocyte differentiation | 6 |
Regulation of glycoprotein biosynthetic process | 2 |
Sertoli cell development | 7 |
Transcription from RNA polymerase II promoter | 302 |
Transcriptional activation by promoter-enhancer looping | 3 |
Cellular components
Name | # of Products |
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Nuclear membrane | 103 |
Nucleolus | 1179 |
Nucleoplasm | 775 |
Nucleus | 4914 |
Transcription factor complex | 286 |
Transcriptional repressor complex | 43 |
Protein function
Name | # of Products |
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C2H2 zinc finger domain binding | 39 |
Chromatin binding | 670 |
DNA binding | 3958 |
DNA binding, bending | 220 |
Enhancer sequence-specific DNA binding | 32 |
Metal ion binding | 5514 |
P53 binding | 139 |
Protein binding | 12191 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | 66 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | 83 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 177 |
RNA polymerase II regulatory region sequence-specific DNA binding | 58 |
RNA polymerase II transcription factor binding | 85 |
Sequence-specific DNA binding | 1803 |
Sequence-specific DNA binding transcription factor activity | 2776 |
Transcription regulatory region sequence-specific DNA binding | 124 |
Zinc ion binding | 3721 |
Diseases
Name | # of Products |
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Disease mutation | 5332 |
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