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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human colon with GRPR polyclonal antibody (Cat # PAB26610). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

  • Specifications

    Product Description

    Rabbit polyclonal antibody raised against synthetic peptide of GRPR.

    Immunogen

    A synthetic peptide corresponding to 17 amino acids from 3rd cytoplasmic domain of human GRPR.

    Host

    Rabbit

    Reactivity

    Bovine, Dog, Hamster, Human, Monkey, Mouse, Pig, Rat

    Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAM28 (41%).

    Form

    Liquid

    Purification

    Immunoaffinity chromatography

    Recommend Usage

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS (0.09% sodium azide)

    Storage Instruction

    Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human colon with GRPR polyclonal antibody (Cat # PAB26610). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

    Immunocytochemistry

  • Gene Info — GRPR

    Entrez GeneID

    2925

    Protein Accession#

    P30550

    Gene Name

    GRPR

    Gene Alias

    -

    Gene Description

    gastrin-releasing peptide receptor

    Omim ID

    305670

    Gene Ontology

    Hyperlink

    Gene Summary

    Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq

    Other Designations

    GRP-preferring bombesin receptor|OTTHUMP00000022983

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