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> L-Ascorbic Acid, 2-Phosphate Magnesium Salt Hydrate

L-Ascorbic Acid, 2-Phosphate Magnesium Salt Hydrate

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Referentie A3775-01B-5g

Formaat : 5g

Merk : US Biological

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A3775-01B L-Ascorbic Acid, 2-Phosphate Magnesium Salt Hydrate

Clone Type
Polyclonal
Grade
Cell Culture Grade
Shipping Temp
RT
Storage Temp
-20°C

L-Ascorbic acid is essential for the synthesis of collagen, with deficiency resulting in scurvy.1 Notably, humans and other primates, guinea pigs, and certain other animals lack an enzyme necessary for vitamin C synthesis.1 L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture. It may be included in media to enhance the survival of human embryonic stem cells or increase the growth and replicative lifespan of human corneal endothelial cells.AA2P is also used to drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells.||Synonyms:|Ascorbic acid phosphate dimagnesium salt; Ascorbyl PM; Magnesium ascorbyl phosphate; Phospitan C||CAS No:|1713265-25-8||Molecular Formula:|C₆H₉O₉P•1.5MgxH2O||Molecular Weight:|292.6||Purity:|≥95%||Appearance:|Crystalline solid||Lambda Max:|259nm||Storage & Stability: |Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. Make fresh. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.|

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
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References
1. Gropper, S.S., Smith, J.L., and Groff, J.L. The water-soluble vitamins, Chapter 9, in Advanced Nutrition and Human Metabolism. 4, Thomson Wadsworth, 259-275 (2005). 2. Kurata, S. and Hata, R. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. J. Biol. Chem. 266(15), 9997-10003 (1991). 3. Yoshikawa, K., Takahashi, S., Imamura, Y., et al. Secretion of non-helical collagenous polypeptides of α1(IV) and α2(IV) chains upon depletion of ascorbate by cultured human cells. J. Biochem. 129(6), 929-936 (2001).|4. Furue, M.K., Na, J., Jackson, J.P., et al. Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. Proc. Natl. Acad. Sci. USA 105(36), 13409-13414 (2008). 5. Kimoto, M., Shima, N., Yamaguchi, M., et al. Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate. Invest. Ophthalmol. Vis. Sci. 53(12), 7583-7589 (2012). 6. Kyllönen, L., Maimi, S., Mannerström, B., et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro. Stem Cell Res. Ther. 4(1), 1-15 (2013). 7. Fang, X., Murakami, H., Demura, S., et al. A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgery. PLoS One 9(2), 1-6 (2014). 8. Mariner, P.D., Johannesen, E., and Anseth, K.S. Manipulation of miRNA activity accelerates osteogenic differentiation of hMSCs in engineered 3D scaffolds. J. Tissue Eng. Regen. Med. 6(4):314-324 (2012).

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