B7767-50mg | Rose Bengal [632-69-9] Clinisciences

Background

Ki: 19 and 64 nM for VGlut andVMAT, respectively

Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor.

The common biochemical l-glutamate (Glu) is widely recognized as the major excitatory neurotransmitter in the vertebrate CNS. Proper Glu transmission plays a critical role in physiological brain functions, such as learning and memory formation as well as basic neural communication.

In vitro: Rose Bengal was a quite potent membrane-permeant inhibitor of glutamate uptake into isolated synaptic vesicles. Such vesicular Glu uptake inhibition was achieved without affecting H1-pump ATPase. It was found that various degrees of reduction elicited by Rose Bengal in [3H]Glu in synaptic vesicles inside the synaptosome [1].

In vivo: The distribution of i.v. administered rose bengal was found to depend on its dose. At a low dose, rose bengal could be found almost solely in the liver and plasma. However, at higher doses, the amount of rose bengal found in extra-hepatic tissues gradually increased. The hepatic transfer maximum of rose bengal amounted to 146 micrograms/kg/min. By increasing the dose from 10 to 200 mg/kg, the hepatic concentration of rose bengal also approached a maximum. The storage capacity of the liver, however, did not limit the transfer maximum of rose bengal [1].

Clinical trial: N/A

References:
[1] Ogita K,Hirata K,Bole DG,Yoshida S,Tamura Y,Leckenby AM,Ueda T. Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem.2001 Apr;77(1):34-42.
[2] Fischer E,Varga F. Hepatic storage and biliary excretion of rose bengal in the rat. Acta Physiol Acad Sci Hung.1979;54(1):89-94.

Product Citation

1. Hong-Yu Zhou, Ya-Ping Huai, et al. "An enriched environment reduces hippocampal inflammatory response and improves cognitive function in a mouse model of stroke." Neural Regen Res. 2022 Nov;17(11):2497-2503. PMID: 35535902

Chemical Properties

Physical Appearance	Red solid
Storage	Store at RT
M.Wt	1017.64
Cas No.	632-69-9
Formula	C₂₀H₂Cl₄I₄Na₂O₅
Solubility	≥50.5 mg/mL in DMSO
Chemical Name	sodium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
SDF	Download SDF
Canonical SMILES	IC1=C(C(C(C(C(C([O-])=O)=C2Cl)=C(C(Cl)=C2Cl)Cl)=C3C=C4I)=CC(I)=C1[O-])OC3=C(C4=O)I.[Na+].[Na+]
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.00%

Chemical structure

Rose Bengal [632-69-9]

Referentie B7767-50mg

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