Application
| WB, ICC |
---|---|
Primary Accession | Q8IYT8 |
Other Accession | NP_001136082.1 |
Host | Rabbit |
Reactivity | Human, Rat |
Clonality | Polyclonal |
Description | Rabbit Anti-Human ULK2 Polyclonal |
Target/Specificity | Detects ~100 kDa. |
Other Names | Serine/threonine-protein kinase ULK2 Antibody, EC:2.7.11.1 Antibody, Unc 51 (C. elegans) like kinase 2 Antibody, ULK2_HUMAN Antibody, KIAA0623 Antibody, ATG1B Antibody, Serine/threonine protein kinase ULK2 Antibody, Unc-51-like kinase 2 Antibody, Unc 51 like autophagy activating kinase 2 Antibody, Unc51.2 Antibody, ULK2 Antibody, Unc 51 like kinase 2 Antibody, |
Immunogen | Synthetic peptide from the mid-protein of Human ULK2 (aa. 558-569) |
Purification | Peptide Affinity Purified |
Storage | -20ºC |
Storage Buffer | PBS, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | A 1:1000 dilution of SPC-641 was sufficient for detection of ULK2 in 15 µg of Human HeLa Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. |
Cellular Localization | Cytoplasmic Vesicle Membrane | Peripheral Membrane Protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
UNC-51 like kinase 2 (ULK2) is widely expresed and contains an amino-terminal kinase domain followed by a central proline-serine rich domain and a highly conserved carboxy-terminal domain. It has been linked to axon growth and is essential for autophagy. Structurally, ULK2 is similar to ATG1.
References
1. Okazaki N., et al. (2000) Brain Res Mol Brain Res. 85: 1-12.
2. Young A.R., et al. (2006) J Cell Sci. 119: 3888-900.
3. Kamada Y., et al. (2000) J Cell Biol. 150: 1507-13.
4. Lee S.B, et al. (2007) EMBO Rep. 8: 360-5.
5. Hara T., et al. (2008) J Cell Biol. 181: 497-510.