Biorbyt
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Products for advancing your discoveries From antibodies to proteins, biochemicals to ELISA kits, Biorbyt's high quality research products are available for you to enable world class research and contribution to a deeper understanding of life sciences.
A comprehensive catalog of life science research products covering the areas of Neuroscience, Signal transduction, Cell Biology, Cancer Metabolism, Cardiovascular and others
Product range :
Choose from over 100,000 primary antibodies and over 2,000 secondary antibodies. Monoclonals and polyclonals tested in a number of applications - WB, ELISA, IHC, FACS and many more.
Choose from over 7,000 proteins and over 400 active proteins. All of our proteins have been validated for use in ELISAs, WB and IHC-P
We have over 10,000 biochemicals for use in your research.
We have over 2,000 ELISA kits covering many research areas . Each kit comes with a fully detailed protocol and examples of expected results.
Website : https://www.biorbyt.com/
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![SARS-CoV-2 - Acalabrutinib - Candidats thérapeutiques](https://www.clinisciences.com/nl/upload/thumbs/therapeutic-covid-19-ubascr-dcbe47.jpg)
SARS-CoV-2 - Acalabrutinib - Candidats thérapeutiques
Acalabrutinib (or Calquence) is an inhibitor of Bruton's tyrosine kinase (BTK). By inactivating the BTK, acalabrutinib prevents activation of the B-cell antigen receptor (BCR) signaling pathway. The B cell activation and downstream survival pathways of B-cells are thus inhibited and, as a result, the growth of malignant B cells that overexpress B-cells is inhibited. It is for this mode of action that acalabrutinib is used in the treatment of certain types of non-Hodgkin's lymphoma such as mantle cell lymphoma.
A clinical trial is planned to evaluate the effect of acalabrutinib (Calquence) on the exaggerated immune response in patients with severe coronavirus 2019 infection (Covid-19). This clinical study was based on preliminary scientific and clinical data on the BTK pathway and its role in the production of inflammatory cytokines. The purpose of the study was to evaluate the efficacy of acalabrutinib in reducing mortality and ventilation support requirements for patients with severe symptoms of Covid-19.
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- Biochemicals 41
- Chromatography 3
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