Biorbyt
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Products for advancing your discoveries From antibodies to proteins, biochemicals to ELISA kits, Biorbyt's high quality research products are available for you to enable world class research and contribution to a deeper understanding of life sciences.
A comprehensive catalog of life science research products covering the areas of Neuroscience, Signal transduction, Cell Biology, Cancer Metabolism, Cardiovascular and others
Product range :
Choose from over 100,000 primary antibodies and over 2,000 secondary antibodies. Monoclonals and polyclonals tested in a number of applications - WB, ELISA, IHC, FACS and many more.
Choose from over 7,000 proteins and over 400 active proteins. All of our proteins have been validated for use in ELISAs, WB and IHC-P
We have over 10,000 biochemicals for use in your research.
We have over 2,000 ELISA kits covering many research areas . Each kit comes with a fully detailed protocol and examples of expected results.
Website : https://www.biorbyt.com/
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![Phosphatidyl Glycerol](https://www.clinisciences.com/nl/upload/bandeau3-9pw8hz2z-7wuq4zmd-b664f4-pv6rfc.png)
Phosphatidyl Glycerol
Phosphatidylglycerol (PG) is a phospholipid that can be used as a detergent for membrane proteins, particularly in studies where a more native-like lipid environment is desired. While traditional detergents are often synthetic molecules, phospholipids like PG offer a more biomimetic approach due to their natural occurrence in biological membranes. Here are key considerations regarding the use of PG as a detergent for membrane proteins:
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Phospholipid Structure: PG consists of a glycerol backbone, two fatty acid chains, a phosphate group, and a glycerol. Its amphipathic nature allows it to interact with both hydrophobic and hydrophilic regions of membrane proteins, mimicking the lipid bilayer environment.
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Biomimicry: PG is a major component of bacterial membranes and is also found in the inner mitochondrial membrane. Using PG as a detergent provides a lipid environment more akin to the native membrane, enhancing the preservation of the native conformation and functionality of membrane proteins.
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Stability of Membrane Proteins: Phospholipids like PG can contribute to the stability of membrane proteins during solubilization. The native-like lipid environment may help retain the structural integrity of proteins, crucial for downstream analyses such as structural determination or functional assays.
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Interaction with Lipid Domains: PG can play a role in the formation of lipid domains within membranes. This property is relevant when studying membrane proteins associated with specific lipid microenvironments or lipid rafts.
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Minimal Interference: PG, being a natural component of cellular membranes, may introduce less interference in downstream applications compared to some synthetic detergents. This is especially important for studies requiring a close representation of the native lipid environment.
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Optimization Considerations: Like any detergent, the effective use of PG requires optimization of concentration, temperature, and lipid-protein interactions to ensure proper solubilization without compromising protein stability.
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Applicability to Specific Proteins: PG may be particularly useful for studies involving bacterial membrane proteins or mitochondrial membrane proteins, where PG is naturally abundant.
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- Biochemicals