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> 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine [89947-80-8]

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine [89947-80-8]

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Referentie HY-154857-1mg

Formaat : 1mg

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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures.

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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine Chemical Structure

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine Chemical Structure

CAS No. : 89947-80-8

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Description

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures[1][2].

IC50 & Target

CD36[2]
Masse moléculaire

595.70

Formule

C28H54NO10P
CAS No.

89947-80-8
Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(C)CCOP(OC[C@H](OC(CCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)([O-])=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureté et documentation
Références

  • [1]. Navaneethan U, et al Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun;109(6):895-902.  [Content Brief]

    [2]. Gao D, et al. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. J Biol Chem. 2010 Feb 12;285(7):4447-54.  [Content Brief]

  • [1]. Navaneethan U, et al Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun;109(6):895-902.

    [2]. Gao D, et al. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. J Biol Chem. 2010 Feb 12;285(7):4447-54.

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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine Related Classifications

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Keywords:

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine89947-80-8Othersglycerophosphorylcholineglycerol phosphatecholine and palmitic acidoxidative stressscavenger receptors class BCD36SR-BItumor apoptosismalignant biliary stricturesInhibitorinhibitorinhibit