Anti-TRPV1 antibody (725-839)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TRPV1
Gene ID:	7442
Uniprot ID:	TRPV1_HUMAN
Immunogen Region:	725-839
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 725-839 of human TRPV1 (NP_061197.4).
Immunogen Sequence:	KLLQVGYTPDGKDDYRWCFR VDEVNWTTWNTNVGIINEDP GNCEGVKRTLSFSLRSSRVS GRHWKNFALVPLLREASARD RQSAQPEEVYLRQFSGSLKP EDAEVFKSPAASGEK

Tissue Specificity	Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Post Translational Modifications	Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
Function	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
Protein Name	Transient Receptor Potential Cation Channel Subfamily V Member 1 Trpv1 Capsaicin Receptor Osm-9-Like Trp Channel 1 Otrpc1 Vanilloid Receptor 1
Database Links	Reactome: R-HSA-3295583
Cellular Localisation	Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendritic Spine Membrane Cell Membrane Mostly But Not Exclusively Expressed In Postsynaptic Dendritic Spines
Alternative Antibody Names	Anti-Transient Receptor Potential Cation Channel Subfamily V Member 1 antibody Anti-Trpv1 antibody Anti-Capsaicin Receptor antibody Anti-Osm-9-Like Trp Channel 1 antibody Anti-Otrpc1 antibody Anti-Vanilloid Receptor 1 antibody Anti-TRPV1 antibody Anti-VR1 antibody

Information sourced from Uniprot.org

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