Our ERBB2 FISH probe is designed to detect ERBB2 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
Gene Background: ERBB2 is a member of the receptor tyrosine kinase family, a subset of receptor proteins that bind epidermal growth factor (EGF).1 ERBB2 doesn’t have a binding domain itself, but stabilizes the configurations of other receptor proteins, making it easier for EGF to latch on.1 ERBB2 is involved in a lengthy list of important signaling cascades, as EGF is a ubiquitous mitogenic factor that stimulates cell growth in many tissue types.2 ERBB2’s oncogenic effects first came to light in 1987, when it was found to play a major role in breast cancer metastasis.3 The gene remains primarily associated with breast cancer (20-30% of breast cancer patients have amplified ERBB2) but it’s now also considered an important oncogene in uterine, gastric, pancreatic, colorectal and endometrial cancer, among others.4,5
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ERBB2
Gene Name: Erb-b2 Receptor Tyrosine Kinase 2
Chromosome: CHR17: 37844392-37884915
Locus: 17q12