GAD67 (GAD1) Rabbit Polyclonal Antibody
Referentie AP06130PU-N
Formaat : 100ug
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GAD67 (GAD1) Rabbit Polyclonal Antibody
SKU
AP06130PU-N
GAD67 (GAD1) rabbit polyclonal antibody, Aff - Purified
| Product Data | |
| Application | IHC, WB |
|---|---|
| Application | Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide, corresponding to amino acids 460-514 of Human GAD-67. |
| Specificity | The antibody detects endogenous levels of GAD67 protein. (region surrounding Ala492) |
| Buffer | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium azide |
| Concentration | <span>1.0 mg/ml</span> |
| Purification | Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Predicted Protein Size | ~ 67 kDa |
| Gene Name | glutamate decarboxylase 1 |
| Database Link | |
| Background | GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (γ-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form. |
| Synonyms | Glutamate decarboxylase 1, GAD-67 |
| Reference Data | |
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