GluA1/GluR1 Glutamate Receptor Antibody
Referentie OASE00288
Formaat : 100ug
Merk : Aviva Systems Biology
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Telefoonnummer : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for OASE00288 |
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| Predicted Species Reactivity | Human, Mouse, Rat |
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| Clonality | Monoclonal |
| Clone | S355-1 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | Unconjugated |
| Application | WB, IHC, ICC, IF |
| Additional Information | Background Info: Detects ~100kDa. Does not cross-react with GluR2. |
| :: | Scientific Background: Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3). |
| :: | Certificate of Analysis: 1ug/mL was sufficient for detection of GluA1/GluR1 in 20ug of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Reconstitution and Storage | Store at -20C. Shipping with Blue Ice or 4C. |
| Immunogen | Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1 |
| Purification | Protein G Purified |
| Concentration | 1 mg/ml |
| Specificity | Detects ~100kDa. Does not cross-react with GluR2. |
| Dilution | WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user. |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Reference | 1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057. |
| Description | Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3). |
| Gene Symbol | GluR1 |
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| Gene Full Name | glutamate receptor, ionotropic, AMPA 1 |
| Alias Symbols | AMPA 1, AMPA selective glutamate receptor 1, Glutamate receptor 1, GluA1, GLUH 1, GluR K1, GluRK1, Glr-1, Glur-1, HIPA, Glur1, GluR-A, AI853806, 2900051M01Rik, GluRA, Glr1, MGC13325, GLUH1, GluA1, GLUR1, HBGR1, GLURA, gluR-, GluA1, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic, Gria 1, HBGR1, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243 |
| NCBI Gene Id | 50592 |
| Uniprot ID | P19490 |
| Protein Accession # | NP_113796 |
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What is the species homology for "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".
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How long will it take to receive "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
This target may also be called "AMPA 1, AMPA selective glutamate receptor 1, Glutamate receptor 1, GluA1, GLUH 1, GluR K1, GluRK1, Glr-1, Glur-1, HIPA, Glur1, GluR-A, AI853806, 2900051M01Rik, GluRA, Glr1, MGC13325, GLUH1, GluA1, GLUR1, HBGR1, GLURA, gluR-, GluA1, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic, Gria 1, HBGR1, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243" in publications.
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What is the shipping cost for "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
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What is the guarantee for "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "GluA1/GluR1 Glutamate Receptor Antibody (OASE00288)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "GluR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "GluR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "GluR1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "GluR1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "GluR1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "GluR1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.