Glutamate Receptor 2 Positive Control peptide

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GRIA2
Gene ID:	2891
Uniprot ID:	GRIA2_HUMAN

Post Translational Modifications	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation. Ubiquitinated by RNF167, leading to its degradation.
Function	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system. It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Peptide Name	Glutamate Receptor 2 Glur-2 Ampa-Selective Glutamate Receptor 2 Glur-B Glur-K2 Glutamate Receptor Ionotropic - Ampa 2 Glua2
Database Links	Reactome: R-HSA-399710 Reactome: R-HSA-416993 Reactome: R-HSA-438066 Reactome: R-HSA-9022699 Reactome: R-HSA-9620244
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Endoplasmic Reticulum Membrane Postsynaptic Cell Membrane Postsynaptic Density Membrane Interaction With Cacng2 Cnih2 And Cnih3 Promotes Cell Surface Expression Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Alternative Peptide Names	Glutamate Receptor 2 protein Glur-2 protein Ampa-Selective Glutamate Receptor 2 protein Glur-B protein Glur-K2 protein Glutamate Receptor Ionotropic - Ampa 2 protein Glua2 protein GRIA2 protein GLUR2 protein

Information sourced from Uniprot.org

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