A7024-25g | HOAt [39968-33-7] Clinisciences

A coupling activator for racemization-free coupling in peptide synthesis; An additive for peptide segment coupling in in reducing the extent of configurational loss at the reactive carboxylic acid residue. Carpino L A etc. works demonstrated that the DIC/HOAt system is more effective in preserving configuration for peptide segment coupling than the analogous DIC/HOBt system

in DMF and DCM. [1]

Reference:
Carpino L A, El-Faham A. The diisopropylcarbodiimide/1-hydroxy-7-azabenzotriazole system: segment coupling and stepwise peptide assembly[J]. Tetrahedron, 1999, 55(22): 6813-6830.

Physical Appearance	A solid
Storage	Desiccate at -20°C
M.Wt	136.11
Cas No.	39968-33-7
Formula	C₅H₄N₄O
Solubility	≥3.62 mg/mL in H2O with ultrasonic; ≥6.81 mg/mL in DMSO; ≥9.29 mg/mL in EtOH with ultrasonic
Chemical Name	3-hydroxytriazolo[4,5-b]pyridine
SDF	Download SDF
Canonical SMILES	C1=CC2=C(N=C1)N(N=N2)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Purity = 99.88%

HOAt [39968-33-7]

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