Human CD45C Antibody : APC
Referentie OASB02625
Formaat : 25tests
Merk : Aviva Systems Biology
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Human CD45C Antibody : APC (OASB02625)
| Datasheets/Manuals | Printable datasheet for Human CD45C Antibody : APC (OASB02625) |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | APC |
| Application | FC |
| Additional Information | Description: CD45, also known as the leukocyte common antigen (LCA), exists as four different isoforms (180, 190, 205, 220 kDa) that are generated by alternative splicing of three exons. LCA is found on all cells of hematopoietic origin, except erythrocytes and platelets. CD45 expression is required for T cell and B cell antigen receptor-mediated activation. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Purified T cells from human lymph nodes |
| Concentration | Lot specific |
| Specificity | CD45 |
| Gene Symbol | PTPRC, PTPRC |
|---|---|
| Gene Full Name | protein tyrosine phosphatase receptor type C |
| Alias Symbols | LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180 |
| NCBI Gene Id | 5788; 100061950 |
| Protein Name | receptor-type tyrosine-protein phosphatase C |
| Description of Target | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. |
| Uniprot ID | P08575, F6WER3 |
| Protein Accession # | NP_002829.3 |
| Nucleotide Accession # | NM_002838.4 |
