Human CD95 Antibody : PE
Referentie OASB02633
Formaat : 25tests
Merk : Aviva Systems Biology
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Telefoonnummer : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for Human CD95 Antibody : PE (OASB02633) |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Additional Information | Description: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Human CD95 transfected L cells |
| Concentration | Lot specific |
| Specificity | CD95 |
| Gene Symbol | FAS, FAS, FAS, FAS |
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| Gene Full Name | Fas cell surface death receptor |
| Alias Symbols | APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6 |
| NCBI Gene Id | 355; 574332; 103216224; 105587157 |
| Protein Name | tumor necrosis factor receptor superfamily member 6 |
| Description of Target | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Uniprot ID | P25445, Q9BDP2, Q9BDN4 |
| Protein Accession # | NP_000034.1 |
| Nucleotide Accession # | NM_000043.5 |
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What is the species homology for "Human CD95 Antibody : PE (OASB02633)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
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How long will it take to receive "Human CD95 Antibody : PE (OASB02633)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "Human CD95 Antibody : PE (OASB02633)" provided in?
This item is provided in "Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Human CD95 Antibody : PE (OASB02633)"?
This target may also be called "APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6" in publications.
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What is the shipping cost for "Human CD95 Antibody : PE (OASB02633)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
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What is the guarantee for "Human CD95 Antibody : PE (OASB02633)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Human CD95 Antibody : PE (OASB02633)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Human CD95 Antibody : PE (OASB02633)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FAS"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FAS"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FAS"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FAS"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FAS"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FAS"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.