LRP5L Polyclonal Antibody, APC-Cy7 Conjugated
Referentie bs-11590R-APC-Cy7
Formaat : 100ul
Merk : Bioss
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Telefoonnummer : +1 850 650 7790
LRP5L Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11590R-APC-Cy7 |
| Product Name | LRP5L Polyclonal Antibody, APC-Cy7 Conjugated |
| Applications | WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Sheep, Chicken |
| Specifications | |
| Conjugation | APC-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human LRP5L |
| Immunogen Range | 101-200/252 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | Low-density lipoprotein receptor-related protein 5-like protein; LRP-5-like; LRP5L; GP330; LRP5L_HUMAN. |
| Background | Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP5L is a related protein that exists as two isoforms produced by alternative splicing. |
| Application Dilution | |
| WB | 1:300-5000 |
| IF(IHC-P) | 1:50-200 |
| IF(IHC-F) | 1:50-200 |
| IF(ICC) | 1:50-200 |