Mouse Anti-Human CD4-AF647
Referentie 9522-31
Formaat : 100tests
Merk : Southern Biotech
Neem contact op met een lokale distributeur :
Telefoonnummer : +1 850 650 7790
| Clone | RFT4 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | Mouse IgG1-AF647 (15H6) |
| Specificity | Human CD4 |
| Alternative Names | T4, Leu-3 |
| Description | CD4 is a 55 kDa type I transmembrane glycoprotein and a member of the Ig-SF of cell surface receptors. It is expressed predominantly on the “helper/inducer” subpopulation of mature T lymphocytes and on monocytes and macrophages. Domains 1 and 2 bind to MHC Class II antigens, while domains 3 and 4 may be involved in cis interactions with the CD3/TCR complex. CD4 functions as an accessory molecule in the recognition of foreign antigens in association with MHC class II antigens by T cells. |
| Immunogen | Thymocytes and E-rosetted lymphocytes |
| Conjugate | AF647 (Alexa Fluor® 647) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light |
| Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
| Applications | Flow Cytometry – Quality tested 1,7-9 Immunohistochemistry-Frozen Sections – Reported in literature 3 Immunocytochemistry – Reported in literature 4,5 Western Blot – Reported in literature 2 Separation – Reported in literature 6 |
| RRID Number | AB_2796861 |
| Gene ID | 920 (Human) |
| Gene ID Symbol | CD4 (Human) |
| Gene ID Aliases | CD4mut |
| UniProt ID | P01730 (Human |
| UniProt Name | CD4_HUMAN (Human) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 7. Daubenberger CA, Salomon M, Vecino W, Hübner B, Troll H, Rodriques R, et al. Functional and structural similarity of Vγ9V δ2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. J Immunol. 2001;167:6421-30. (FC)
- 8. Zariffard MR, Saifuddin M, Finnegan A, Spear GT. HSV type 2 infection increases HIV DNA detection in vaginal tissue of mice expressing human CD4 and CCR5. AIDS Res Hum Retroviruses. 2009;25:1157-64. (FC)
- 9. Roetynck S, Olotu A, Simam J, Marsh K, Stockinger B, Urban B, et al. Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure. PLoS One. 2013;8(1):e55195. (FC)