Mouse Anti-Human FADD-HRP
Referentie 10941-05
Formaat : 1.0mL
Merk : Southern Biotech
Clone | 1A11 |
---|---|
Isotype | Mouse (BALB/c) IgG1κ |
Isotype Control | Mouse IgG1-HRP (15H6) |
Specificity | Human FADD |
Alternative Names | FAS-associated death domain protein, GIG3, MGC8528, MORT1 |
Description | Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. |
Immunogen | Recombinant FADD |
Conjugate | HRP (Horseradish Peroxidase) |
Buffer Formulation | 50% Glycerol/50% Phosphate buffered saline, pH 7.4 |
Clonality | Monoclonal |
Concentration | Lot specific |
Volume | 1.0 mL |
Recommended Storage | 2-8°C |
Applications | ELISA – Quality tested Western Blot – Quality tested Immunoprecipitation – Quality tested |
RRID Number | AB_2794560 |
Gene ID | 8772 (Human) |
Gene ID Symbol | FADD (Human) |
Gene ID Aliases | GIG3; MORT1 |
UniProt ID | Q13158 (Human |
UniProt Name | FADD_HUMAN (Human) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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