Mouse VCL (Vinculin) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Vcl
Gene ID:	22330
Uniprot ID:	VINC_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylated.on serines, threonines and tyrosines. Phosphorylation on Tyr-1065 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques. Acetylated.mainly by myristic acid but also by a small amount of palmitic acid.
Function	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Protein Name	Vinculin Metavinculin
Database Links	Reactome: R-MMU-114608 Reactome: -MMU-445355 Reactome: -MMU-5674135 Reactome: -MMU-6798695
Cellular Localisation	Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Junction Adherens Junction Focal Adhesion Cytoplasm Cytoskeleton Sarcolemma Cell Projection Podosome Recruitment To Cell-Cell Junctions Occurs In A Myosin Ii-Dependent Manner Interaction With Ctnnb1 Is Necessary For Its Localization To The Cell-Cell Junctions
Alternative ELISA Names	Vinculin ELISA kit Metavinculin ELISA kit Vcl ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance