Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Yellow oil
Purity:
98% by TLC NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
Size :
Quantity
5 mg
$50.00
25 mg
$195.00
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N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry in human platelets3. Topical AFC has been shown to inhibit neutrophil chemotaxis and other inflammatory responses without systemic effects.4,5
References/Citations:
1) Volker et al. (1991), Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem. 266 21515 2) Xu et al. (1996), Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol. 50 1495 3) Rosado and Sage (2000), Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J. 347 183 4) Gordon et al. (2008), Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol. 128 643 5) Adhami et al. (2012), N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells; Exp. Dermatol. 21 700
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee
N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry in human platelets3. Topical AFC has been shown to inhibit neutrophil chemotaxis and other inflammatory responses without systemic effects.4,5
References/Citations:
1) Volker et al. (1991), Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem. 266 21515 2) Xu et al. (1996), Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol. 50 1495 3) Rosado and Sage (2000), Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J. 347 183 4) Gordon et al. (2008), Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol. 128 643 5) Adhami et al. (2012), N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells; Exp. Dermatol. 21 700
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