C5155-5mg | Nourseothricin (sulfate) [96736-11-7] Clinisciences

Background

Nourseothricin is a broad-spectrum antibiotic.

Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei.

In vitro: Nourseothricin, represents a mixture of streptothricins, mainly D and F. Although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. It has been also shown that nourseothricin was able to generate some channels into the outer membrane. Moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. In addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1].

In vivo: Animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. Renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. Following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. There was a high degree of accumulation of nourseothricin in renal cortical slices. In contrast to PAH accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. Age dependent differences in nourseothricin accumulation did not exist [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Seltmann G. Resistance of Escherichia coli to nourseothricin (streptothricin): sensitization of resistant strains by abolition of its outer membrane resistance. Zentralbl Bakteriol. 1992 Jan;276(2):143-51.
[2] Brunlich H, Hoffmann H, Bocker H. Renal handling of nourseothricin. Pharmazie. 1988 Mar;43(3):200-2.

Chemical Properties

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	1359.48
Cas No.	96736-11-7
Formula	C₃₁H₅₈N₁₂O₁₀·C₁₉H₃₄N₈O₈·H₂SO₄
Synonyms	clonNAT; Streptothricin; Streptothricin sulfate
Solubility	≤10mg/ml in PBS, pH 7.2
Chemical Name	sulfuric acid--(2R,3R,4S,5R,6R)-5-((S)-3,6-diaminohexanamido)-4-hydroxy-6-(((3aS,7R,7aS)-7-hydroxy-4-oxo-3a,4,5,6,7,7a-hexahydro-1H-imidazo[4,5-c]pyridin-2-yl)amino)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl carbamate--(2R,3R,4S,5R,6R)-5-((S)-3-amino-6-((
SDF	Download SDF
Canonical SMILES	O=C(C[C@@H](N)CCCN)N[C@H]1[C@H](NC2=N[C@@](C(NC[C@H]3O)=O)(11)[C@]3(11)N2)O[C@H](CO)[C@H](OC(N)=O)[C@H]1O.OS(=O)(O)=O.O=C(C[C@@H](N)CCCNC(C[C@@H](N)CCCNC(C[C@@H](N)CCCN)=O)=O)N[C@H]4[C@H](NC5=N[C@@](C(NC[C@H]6O)=O)(11)[C@]6(11)N5)O[C@H](CO)[C@H](OC(N)
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.00%

Chemical structure

Nourseothricin (sulfate) [96736-11-7]

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Background

Chemical Properties

Quality Control

Chemical structure

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