PERK Polyclonal Antibody, Biotin Conjugated
Referentie bs-2469R-Biotin
Formaat : 100ul
Merk : Bioss
PERK Polyclonal Antibody, Biotin Conjugated
Applications
Reactivity
Overview | |
Catalog # | bs-2469R-Biotin |
Product Name | PERK Polyclonal Antibody, Biotin Conjugated |
Applications | WB, ELISA, IHC-P, IHC-F |
Reactivity | Human, Mouse, Rat |
Specifications | |
Conjugation | Biotin |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human PER |
Immunogen Range | 1001-1116/1116 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C for 12 months. |
Target | |
Gene ID | 9451 |
Swiss Prot | Q9NZJ5 |
Subcellular location | Cytoplasm |
Synonyms | PEK; WRS; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK; EIF2AK3 |
Background | Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). |
Application Dilution | |
WB | 1:300-5000 |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |