Polymyxin B [1404-26-8]
Referentie HY-149179-100mg
Formaat : 100mg
Merk : MedChemExpress
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Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research.
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Polymyxin B Chemical Structure
CAS No. : 1404-26-8
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
| Description |
Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3]. |
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| In Vitro |
Polymyxin B (10 μg/mL, 6 h) decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| In Vivo |
Polymyxin B (5-20 mg/kg for i.v; once daily for seven days) reaches the nephrotoxicity endpoint at 20 mg/kg instead of 5 mg/kg in Sprague-Dawley rats model[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| CAS No. |
1404-26-8 |
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| Appearance |
Solid |
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| Color |
White to light yellow |
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| SMILES |
[Polymyxin B] |
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| Livraison | Room temperature in continental US; may vary elsewhere. |
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| Stockage |
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| Solvant et solubilité |
In Vitro:
H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with HCl)
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Pureté et documentation |
Purity: ≥91.0% |
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| Références |
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