Polymyxin B (Sulfate) [1405-20-5]
Referentie HY-A0248-5g
Formaat : 5g
Merk : MedChemExpress
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo.
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Polymyxin B Sulfate Chemical Structure
CAS No. : 1405-20-5
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Description |
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo[1][2][3]. |
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In Vitro |
Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Masse moléculaire |
1199.75 (average) |
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CAS No. |
1405-20-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=S(O)(O)=O.O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]1(00)[C@H](O)C)=O)CCN)=O)(00)CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC1=O)(00)NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCCC(C)C)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2.O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]3(00)[C@H](O)C)=O)CCN)=O)(00)CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC3=O)(00)NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCC[C@@H](C)CC)=O)=O)=O)=O)=O)CCN)=O)CC4=CC=CC=C4 |
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Structure Classification |
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Initial Source |
Bacillus polymyxa |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvant et solubilité |
In Vitro:
DMSO : 33.33 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 16.67 mg/mL (Need ultrasonic)
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||||||
Références |
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Polymyxin B Sulfate Related Classifications
- Peptides
- Peptide and Derivatives
- Antimicrobial Peptides
- Anti-infection
- Bacterial Antibiotic