PSMD4 Antibody - C-terminal region
Referentie ARP32341_P050-25UL
Formaat : 25ul
Merk : Aviva Systems Biology
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PSMD4 Antibody - C-terminal region (ARP32341_P050)
| Datasheets/Manuals | Printable datasheet for anti-PSMD4 (ARP32341_P050) antibody |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | IHC, WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human PSMD4 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: VMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-PSMD4 (ARP32341_P050) antibody is Catalog # AAP32341 (Previous Catalog # AAPP03330) |
| Sample Type Confirmation | PSMD4 is strongly supported by BioGPS gene expression data to be expressed in Raji |
| Subunit | 4 |
| Reference | Fujiwara,K., et al., (2004) J. Biol. Chem. 279 (6), 4760-4767 |
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| Gene Symbol | PSMD4 |
| Gene Full Name | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
| Alias Symbols | AF, ASF, S5A, AF-1, MCB1, Rpn10, pUB-R5 |
| NCBI Gene Id | 5710 |
| Protein Name | 26S proteasome non-ATPase regulatory subunit 4 |
| Description of Target | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid. |
| Uniprot ID | P55036 |
| Protein Accession # | NP_002801 |
| Nucleotide Accession # | NM_002810 |
| Protein Size (# AA) | 377 |
| Molecular Weight | 41kDa |
| Protein Interactions | UBC; cdc20; XPC; SPRTN; PSMD14; MDM2; PSMC2; PSMA1; ADRM1; UBQLN1; TXNL1; PSMD3; PSMD2; PSMD1; PSMC6; PSMC4; PSMC1; UCHL5; RPS12; PSMD8; UBQLN4; VCP; GJA1; DIO2; SCHIP1; FBXO6; PARK2; UL76; FBXO25; LOC100044627; Gm4705; LOC677113; Rps6-ps4; Rpl34-ps1; Rpl |
