Rat Anti-Mouse CD38-AF488
Referentie 1640-30
Formaat : 0.1mg
Merk : Southern Biotech
Clone | 90 |
---|---|
Isotype | Rat IgG2aκ |
Isotype Control | Rat IgG2a-AF488 (KLH/G2a-1-1) |
Specificity | Mouse CD38 |
Alternative Names | T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase |
Description | Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. |
Immunogen | Mouse bone marrow pre-B cells |
Conjugate | AF488 (Alexa Fluor® 488) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | 0.5 mg/mL |
Volume | 0.2 mL |
Recommended Storage | 2-8°C; Avoid exposure to light |
Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
Applications | Flow Cytometry – Quality tested 1 Immunohistochemistry-Frozen Sections – Reported in literature 1 Immunoprecipitation – Reported in literature 1 Stimulation – Reported in literature 2 |
RRID Number | AB_2795081 |
Gene ID | 12494 (Mouse) |
Gene ID Symbol | Cd38 (Mouse) |
Gene ID Aliases | I-19; ADPRC 1; Cd38-rs1 |
UniProt ID | P56528 (Mouse |
UniProt Name | CD38_MOUSE (Mouse) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 1. Oliver AM, Martin F, Kearney JF. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol. 1997;158:1108-15. (Immunogen, IP, IHC-FS, FC)
- 2. Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, et al. PECAM1+/Sca1+/CD38+ vascular cells transform into myofibroblast-like cells in skin wound repair. PLoS One. 2013;8(1):e53262. (Stim)