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Growth and Differentiation factor for Stem Cell

Growth and Differentiation factor for Stem Cell

Recombinant growth and differentiation factors commonly used in stem cell culture

 

Growth factors

Haematopoietic growth factors 

     

 Growth factors and cell stimulation
Haematopoietic growth factors commonly used for stem cell culture:
  
Recombinant cell growth and stimulation factors commonly used for stem cell culture:
     
Tissue growth factors   Growth factors for the immune and haematopoietic systems

-Growth factor for bone formation and regeneration: Bone morphogenetic protein-2 (BMP-2)

- Growth factor for tissue repair and angiogenesis: Fibroblast growth factor-2 (FGF-2)

- Growth factor for regeneration and scar tissue formation: Platelet-derived growth factor (PDGF-BB)

 

  
Recombinant growth factors commonly used for stem cell culture:

- Erythropoïétine- α (EPO-alpha)
- Granulocyte macrophage colony-stimulating factor (GM-CSF)
- Interleukin-3 (IL-3)
- Interleukin 6 (IL-6)
- Leukaemia inhibitory factor (LIF)

 Modulators of stem cell fate

Regulators of stem cell fate        Regulators of stem cell fate
 Inhibitors used to support embryonic cell (ES) self-renewal:

- CHI99021: Glycogen synthase kinase 3 (GSK-3) inhibitor
- PD 184352 : Inhibitor of extracellular signal-regulated kinase (ERK)
- SU-5402 : Fibroblast growth factor receptor (FGFR) signalling inhibitor

 

 

 

  

Molecules used for stem cell reprogramming and differentiation:
     
Regulators of stem cell fate   Regulators of stem cell fate 
 

These 3 products contain small molecules that enable fibroblasts to be transformed into stem cells:

- PD 03255901 : Mitogen-activated protein kinase (MEK) inhibitor
- SB-431542 : Type I receptor inhibitor of transforming growth factor beta (TGF-β)
- Thiazovivin : Rho-associated protein kinase (ROCK) inhibitor

  
These molecules are used for the survival of embryonic stem cells (ESCs):

- Pyrintegrin : Integrin activator
- Thiazovivin : Rho-associated protein kinase (ROCK) inhibitor
- Y-27632, HCl : Rho-associated protein kinase (ROCK) inhibitor
     
Regulators of stem cell fate   Regulators of stem cell fate
 

The following products contain small molecules to generate iPSCs from primary cells:

- A-83-01 : TGF-β type I receptor inhibitor
- PD 03255901 : Mitogen-activated protein kinase (MEK) inhibitor
- PS48 : Activation of phosphoinositide-dependent protein kinase-1 (PDK1)
- Butyrate de sodium : Histone deacetylase (HDAC) inhibitor
- Hémisulfate de tranylcyptromine (Parnate) : Specific lysine demethylase 1 (LSD1) inhibitor

  
 Molecules used for iPSC induction:

- A-83-01 : TGF-β type I receptor inhibitor
- CHIR 99021 :Glycogen synthase kinase-3 (GSK-3) inhibitor
- IQ-1 : p300-dependent β-catenin inhibitor
- PD 03255901 : MEK inhibitor
- SU-5402 : Fibroblast growth factor receptor (FGFR) inhibitor
     
Regulators of stem cell fate 
Small molecules used to improve reprogramming efficiency:
  

- RepSox : TGF-β type I receptor inhibitor
- Reversine : Potential aid for cell reprogramming
- RG-108 : DNA methyltransferase (DNMT) inhibitor
- SB-431542 : Inhibits the TGF-β type I receptor
- Butyrate de sodium : Histone deacetylase (HDAC) inhibitor
 - Hémisulfate de tranylcyptromine (Parnate) : Specific lysine demethylase 1 (LSD1) inhibitor
 - VPA : Histone deacetylase (HDAC) inhibitor

Neuronal Transdifferentiation Modulators 

Modulators of neuronal transdifferentiation
 

Modulator molecules used to improve neuronal transdifferentiation:

- SB-431542 : TGF-β type I receptor inhibitor
- LDN193189 : Type I BMP receptor inhibitor
- CHIR 99021 : GSK-3 inhibitor
- Noggin, recombinant humain : Inhibitor of BMP signalling