- More Files
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed, paraffin-embedded human uterus (A) and human adrenal gland (B) tissue after heat-induced antigen retrieval.
Using AGTR2 polyclonal antibody (Cat # PAB25552).
- Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AGTR2.
Immunogen
A synthetic peptide corresponding to 16 amino acids at internal region of human AGTR2.
Host
Rabbit
Reactivity
Bovine, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Sheep
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR65 (63%), NPFFR2 (44%).
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed, paraffin-embedded human uterus (A) and human adrenal gland (B) tissue after heat-induced antigen retrieval.
Using AGTR2 polyclonal antibody (Cat # PAB25552). - Gene Info — AGTR2
Entrez GeneID
186Gene Name
AGTR2
Gene Alias
AT2, ATGR2, MRX88
Gene Description
angiotensin II receptor, type 2
Omim ID
300034Gene Ontology
HyperlinkGene Summary
Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an intergral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame. [provided by RefSeq
Other Designations
OTTHUMP00000023878|angiotensin receptor 2
- Interactomes
- Pathways
- Diseases