Anti-CD10/MME antibody (Clone: CB-CALLA) {AF647}

Clonality:	Monoclonal
Clone ID:	CB-CALLA
Conjugation:	AF647
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	MME
Gene ID:	4311
Uniprot ID:	NEP_HUMAN

Post Translational Modifications	Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
Function	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Protein Name	Neprilysin Atriopeptidase Common Acute Lymphocytic Leukemia Antigen Calla Enkephalinase Neutral Endopeptidase 24.11 Nep Neutral Endopeptidase Skin Fibroblast Elastase Sfe Cd Antigen Cd10
Database Links	Reactome: R-HSA-2022377 Reactome: R-HSA-5578768 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein
Alternative Antibody Names	Anti-Neprilysin antibody Anti-Atriopeptidase antibody Anti-Common Acute Lymphocytic Leukemia Antigen antibody Anti-Calla antibody Anti-Enkephalinase antibody Anti-Neutral Endopeptidase 24.11 antibody Anti-Nep antibody Anti-Neutral Endopeptidase antibody Anti-Skin Fibroblast Elastase antibody Anti-Sfe antibody Anti-Cd Antigen Cd10 antibody Anti-MME antibody Anti-EPN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance