Baricitinib-d5 [1564241-79-7]
Référence HY-15315S-5mg
Conditionnement : 5mg
Marque : MedChemExpress
Baricitinib-d5 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
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Baricitinib-d5 Chemical Structure
CAS No. : 1564241-79-7
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Description |
Baricitinib-d5 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively. |
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In Vitro |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
Masse moléculaire |
376.45 |
Formule |
C16H12D5N7O2S |
CAS No. |
1564241-79-7 |
Unlabeled CAS |
1187594-09-7 |
SMILES |
N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(C([2H])([2H])C([2H])([2H])[2H])=O)C1 |
Livraison | Room temperature in continental US; may vary elsewhere. |
Stockage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
Pureté et documentation | |
Références |
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Baricitinib-d5 Related Classifications
- Inflammation/Immunology
- Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
- JAK
Calculateur de molarité
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Baricitinib-d51564241-79-7LY3009104-d5INCB028050-d5JAKJanus kinaseInhibitorinhibitorinhibit