Application 
| WB, IP, E |
|---|---|
| Primary Accession | O43745 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 22 KDa |
| Gene ID | 63928 |
|---|---|
| Other Names | Calcineurin B homologous protein 2, Hepatocellular carcinoma-associated antigen 520, CHP2, HCA520 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CHP2 |
|---|---|
| Synonyms | HCA520 |
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
| Cellular Location | Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. |
| Tissue Location | Expressed in malignantly transformed cells but not detected in normal tissues. |