Biological Activity

DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.

Customer Product Validations & Biological Datas

	Source	Adv Healthc Mater (2017). Figure 1. DMH1
	Method	RT-PCR
	Cell Lines	hMSCs
	Concentrations	50 μm
	Incubation Time	0, 3, and 14 d
	Results	To evaluate the necessity of ERK1/2 phosphorylation on osteogenic gene expression, PD98059, a selective MEK1/2 inhibitor was used to treat hMSCs cultured on Col-GAG and MC-GAG and quantitative reverse-transcriptase polymerase chain reactions (RT-PCR) was performed in the same manner as the DMH1 experiment.

Chemical Information

Molecular Weight	380.44
Formula	C24H20N4O
CAS Number	1206711-16-1
Solubility (25°C)	DMSO 22 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Yue Sheng, et al. DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy

[2] Xin Xie, et al. DMH1 increases glucose metabolism through activating Akt in L6 rat skeletal muscle cells

[3] Jijun Hao, et al. DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer

[4] M Diana Neely, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction

[5] Ada Ao, et al. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells