GW4869 [6823-69-4]
Référence HY-19363-10mg
Conditionnement : 10mg
Marque : MedChemExpress
GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
GW4869 Chemical Structure
CAS No. : 6823-69-4
This product is a controlled substance and not for sale in your territory.
Based on 177 publication(s) in Google Scholar
Other Forms of GW4869:
- GW4869-13C4 Obtenir un devis
-
GW4869 purchased from MedChemExpress. Usage Cited in: Protein Cell. 21 September 2022.
- The TAZ protein level in PCDH and NDFIP1-OE SPC-A1 and A549 cells with or without GW4869 (5 μM; 24 h).
-
GW4869 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Aug 1;13(1):4461. [Abstract]
- Immunoblot analysis of TβRII in whole cells lysate and EVs from MDA-MB-231 cells with GW4869 (10 μM) treatment for 48 h. Pre-treatment of cells with GW4869, which inhibits the release of extracellular vesicles, also sharply reduced the TβRII levels in the TEVs
-
GW4869 purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Sep 6;12(15):6527-6547. [Abstract]
- The hEECs are pre-treated with 0.1% DMSO or 1 µM GW4869 for 24 h, and then co-cultured with isolated endometrial NK cells for another 24 h, in vitro.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Apr 20;13(4):382. [Abstract]
- Western blotting is used to detect TIMP2 expression in Caki-1 cells and 786-O cells after adding GW4869 (5 μM) to the coculture system.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Mar 26;13(3):271. [Abstract]
- WB analysis of CD63 and CD81 in exosomes extracted from MSC-conditioned medium and GW4869 (10 µM) pretreated MSC-conditioned medium.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2021 Dec;33(49):e2103471. [Abstract]
- Whole cells lysate and EVs derived from Vero-E6 cells treated with control DMSO or GW4869 (10 μM) for 48 h. Pre‐treatment of cells with GW4869, which inhibits the release of extracellular vesicles, also reduced the ACE2 levels in EVs.
-
GW4869 purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2021 Feb;10(4):e12068. [Abstract]
- Representative actin ring and TRAP staining images of BMMs cultured with PC3‐CM depleted EVs using ultracentrifugation or GW4869 (10 μM; 6 h).
-
GW4869 purchased from MedChemExpress. Usage Cited in: Biomaterials. 2021 Dec;279:121223.
- The results also show higher expression of tooth development-related proteins (GLI2, GLI3, DLX1, BMP-2, BMP-4), dentinogenesis-related proteins (DSPP, DMP-4) and cementogenesis-related proteins (CAP, CEMP) in the DA-Exo and GW4869+DA-Exo groups than in the GW4869 (20 μM; 24 h) and hDPSC groups.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Engineering. 19 October 2021.
- In SNU-449 cells, GW4869 (20 μM; 24 h) into the co-culture system and observed that the Cy3-fluorescence of the recipient cells is dramatically weakened.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2021 Jan 5;34(1):108576. [Abstract]
- M1 macrophages are treated with bmiR-29-Exos with or without 10 μM GW4869 for 48 h; then, relative miR-29a expression in macrophages is determined by qPCR.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Mol Ther-Nucl Acids. 2021 Apr 24;24:923-938. [Abstract]
- The diameter of myotubes and the MHC protein expression of the GW4869-treated C26 group were higher than the control C26 group.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Mol Ther-Nucl Acids. 2021 Apr 24;24:923-938. [Abstract]
- The pro-atrophy ability of C26 tumor medium is inhibited by GW4869.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2020 Jan 23;11(1):37. [Abstract]
- Exos-IL6 are added to macrophages to detect inflammatory cytokines, chemokines, and growth factors in cell culture media. GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; MIP-1, macrophage inflammatory protein-1; IP-10, interferon-inducible protein-10; MDC, macrophage-derived chemokine; MCP-1, monocyte chemoattractant protein-1; TNF-ɑ, tumor necrosis factor.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Int J Oncol. 2019 May;54(5):1567-1578. [Abstract]
- Western blot analysis is used to assess levels of exosome markers in hucMMSCs-exos and GW4869-treated hUCMSCs-CM.
-
GW4869 purchased from MedChemExpress. Usage Cited in: Int J Oncol. 2019 May;54(5):1567-1578. [Abstract]
- LSCC cell AMC-HN-8 is treated with 20 μM GW4869 compared with 0.5% DMSO. 20 μM GW4869 can significantly alter the levels of miR-1246 within the LSCC cells and sEV.