Histamine [51-45-6]
Référence HY-B1204-100mg
Conditionnement : 100mg
Marque : MedChemExpress
Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter.
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Histamine Chemical Structure
CAS No. : 51-45-6
This product is a controlled substance and not for sale in your territory.
Based on 8 publication(s) in Google Scholar
Other Forms of Histamine:
- Histamine phosphate In-stock
- Histamine dihydrochloride In-stock
- Histamine-α,α,β,β-d4 dihydrochloride In-stock
Description |
Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. |
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IC50 & Target |
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In Vivo |
Histamine can be used in animal modeling to construct gastrointestinal ulcer models. After intravenous injection of histamine hydrochloride, the maximum concentration and AUC of histamine in liver and liver tumor tissues were higher than those in subcutaneous tissue[1]. Induction of Gastrointestinal Ulcer[2]
Background
Histamine can cause increased gastric acid secretion, decreased mucus production, reflux of pancreatic juice, poor gastric blood flow, and thus gastric ulcers. Stress can cause increased gastrointestinal motility, making the gastric folds more susceptible to damage when exposed to acid.
Specific Modeling Methods
Guinea Pig: male • albino •
Administration: 5 mg/kg • i.p. • single dose
Note
(1) No eating or drinking is allowed 24 hours before the experiment.
(2) The animals are sacrificed 2 hours after histamine injection, and treated with 1% formalin to check for gastric ulcers. Modeling Indicators
The ulcers were punctate or elongated. After the model was dissected, the ulcer index (the sum of the lengths of the lesions) was measured under a microscope to be 3.4 mm.
Correlated Product(s) Serotonin (HY-B1473A)、Reserpine (HY-N0480) Opposite Product(s) Cimetidine (HY-14289) MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
111.15 |
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Formule |
C5H9N3 |
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CAS No. |
51-45-6 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
NCCC1=CN=CN1 |
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Structure Classification |
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Initial Source |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
-20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
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Solvant et solubilité |
In Vitro:
H2O : ≥ 34 mg/mL (305.89 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 8.9969 mL | 44.9843 mL | 89.9685 mL | 224.9213 mL |
5 mM | 1.7994 mL | 8.9969 mL | 17.9937 mL | 44.9843 mL | |
10 mM | 0.8997 mL | 4.4984 mL | 8.9969 mL | 22.4921 mL | |
15 mM | 0.5998 mL | 2.9990 mL | 5.9979 mL | 14.9948 mL | |
20 mM | 0.4498 mL | 2.2492 mL | 4.4984 mL | 11.2461 mL | |
25 mM | 0.3599 mL | 1.7994 mL | 3.5987 mL | 8.9969 mL | |
30 mM | 0.2999 mL | 1.4995 mL | 2.9990 mL | 7.4974 mL | |
40 mM | 0.2249 mL | 1.1246 mL | 2.2492 mL | 5.6230 mL | |
50 mM | 0.1799 mL | 0.8997 mL | 1.7994 mL | 4.4984 mL | |
60 mM | 0.1499 mL | 0.7497 mL | 1.4995 mL | 3.7487 mL | |
80 mM | 0.1125 mL | 0.5623 mL | 1.1246 mL | 2.8115 mL | |
100 mM | 0.0900 mL | 0.4498 mL | 0.8997 mL | 2.2492 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Histamine Related Classifications
- Induced Disease Models Products
- Immunology and Inflammatory Disease Models Digestive System Disease Models
- Gastrointestinal Inflammation and Ulcer Models Gastrointestinal Disease Models
- Gastric Ulcer Models Duodenal Ulcer Models
- GPCR/G Protein Neuronal Signaling Immunology/Inflammation Metabolic Enzyme/Protease
- Histamine Receptor Endogenous Metabolite