B5670-10mg | I-BET 151 hydrochloride [1883545-47-8] Clinisciences

Background

I-BET 151 dihydrochloride is a bET bromodomain inhibitor that prevents BET from recruiting to chromatin. I-BET 151 induces MLL-fusion leukemia cell line apoptosis and G0 / G1 cell cycle arrest in vitro, and reduces BCL2 expression in NOMO1 cells. I-BET 151 improves the survival rate of two kinds of MLL fusion leukemia mice, and enhances the differentiation of human iPSCs into megakaryocytes.

Reference:

[1]. Malherbe P, Masciadri R, Norcross R D, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. British journal of pharmacology, 2008, 154(4): 797.

Product Citation

1. Ramallo IA, Alonso VL, et al. "A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts." ACS Comb Sci.2018 Apr 9;20(4):220-228. PMID:29481050

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	451.9
Cas No.	1883545-47-8
Formula	C₂₃H₂₁N₅O₃·HCl
Solubility	insoluble in H2O; ≥22.05 mg/mL in EtOH; ≥31.7 mg/mL in DMSO
Chemical Name	7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2-ol hydrochloride
SDF	Download SDF
Canonical SMILES	CC1=NOC(C)=C1C2=CC3=NC=C(N=C(O)N4[C@](C5=CC=CC=N5)(22)C)C4=C3C=C2OC.Cl
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 97.99%

Chemical structure

I-BET 151 hydrochloride [1883545-47-8]

Référence B5670-10mg

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