Mouse HBEGF (Heparin Binding Epidermal Growth Factor Like Growth Factor) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Hbegf
Gene ID:	15200
Uniprot ID:	HBEGF_MOUSE
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Most abundant in kidney, skeletal muscle, lung, spleen, brain and heart.
Post Translational Modifications	O-glycosylated.
Function	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Protein Name	Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth Factor Hb-Egf Hbegf
Database Links	Reactome: R-MMU-1227986 Reactome: -MMU-1236394 Reactome: -MMU-1250196 Reactome: -MMU-1250342 Reactome: -MMU-1250347 Reactome: -MMU-1257604 Reactome: -MMU-177929 Reactome: -MMU-179812 Reactome: -MMU-180292 Reactome: -MMU-180336 Reactome: -MMU-182971 Reactome: -MMU-1963640 Reactome: -MMU-1963642 Reactome: -MMU-212718 Reactome: -MMU-2179392 Reactome: -MMU-5673001 Reactome: -MMU-6785631 Reactome: -MMU-6811558 Reactome: -MMU-8847993 Reactome: -MMU-8856825 Reactome: -MMU-8856828 Reactome: -MMU-8857538 Reactome: -MMU-8863795 Reactome: -MMU-9009391
Cellular Localisation	Heparin-Binding Egf-Like Growth Factor: Secreted Extracellular Space Mature Hb-Egf Is Released Into The Extracellular Space And Probably Binds To A Receptor Proheparin-Binding Egf-Like Growth Factor: Cell Membrane Single-Pass Type I Membrane Protein
Alternative ELISA Names	Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth Factor ELISA kit Hb-Egf ELISA kit Hbegf ELISA kit Hbegf ELISA kit Dtr ELISA kit Hegfl ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance