PrP (AH6)
Référence sc-69896
Conditionnement : 200µg/ml
Marque : Santa Cruz Biotechnology
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Anticorps PrP (AH6): sc-69896
- L'Anticorps PrP (AH6) est un monoclonal de souris IgG2a κ, cité dans 4 publications, fourni en 200 µg/ml
- raised against recombinant full length PrP of ovine origin
- recommandé pour la détection de C-terminal amino acid residues 90-230 of PrP d'origine mouse, rat, human, ovine, hamster et deer par WB, IP, FCM et ELISA
- disponible conjugué soit à la phycoérythrine soit à la FITC pour IF, IHC(P) et FCM
- est le réactif secondaire recommandé pour la détection de l'anticorps PrP (AH6) pour des applications de WB. Ce réactif est maintenant proposé en kit avec l'anticorps PrP (AH6) ().
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Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc, through alterations in the protein folding conformations. PrPc is constitutively expressed in normal adult brain and is sensitive to proteinase K digestion, while the altered PrPSc conformation is resistant to proteases, resulting in a distinct molecular mass after PK treatment. Consistent with the transient infection process of prion diseases, incubation of PrPc with PrPSc both in vitro and in vivo produces PrPc that is resistant to protease degradation. Infectious PrPSc is found at high levels in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Cruetzfeldt-Jakob disease in humans.
| Espèces | Nom du Gène | Gene ID | Localisation chromosomique | Numéro d'accession de l'isoforme (ARNm) | Numéro d'accès aux protéines | Numéro OMIM™ |
|---|---|---|---|---|---|---|
| Human | PRNP | Entrez Gene ID: 5621 | 20p13 | NM_000311, NM_001080121, NM_001080122, NM_001080123, NM_001271561, NM_183079 | UniProt ID: F7VJQ1 | 606688 |
| Mouse | Prnp | Entrez Gene ID: 19122 | 2 F2 | NM_001278256, NM_011170 | UniProt ID: P04925 | N/A |
L'anticorps PrP préféré est l'Anticorps PrP (8B4): sc-47729.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PrP (AH6) | sc-69896 | 200 µg/ml | .00 | |||
PrP (AH6): m-IgG2a BP-HRP Kit | sc-546003 | 200 µg Ab; 10 µg BP | .00 | |||
Anticorps PrP (AH6) FITC | sc-69896 FITC | 200 µg/ml | .00 | |||
Anticorps PrP (AH6) PE | sc-69896 PE | 200 µg/ml | .00 |
Can PrP (AH6): sc-69896 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?
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